CAREER: Artificial Extracellular Matrix Biosensors (e-ECM)

最近的可穿戴生物传感器是建立在平面，刚性薄膜。这些生物传感器的边界导致炎症反应和不准确的测量，这对长期使用和可靠性提出了挑战。该提案旨在开发一种柔软的生物集成监测系统，该系统概括了天然组织的特性。柔性、可拉伸、多孔和基于纤维的生物传感器将被设计和验证为真实的临界生物标志物浓度。该项目的教育方面将侧重于创造基于科学的玩具，以了解廉价材料的生物医学工程基础。这些课程将与新的教育模块相结合。本科生和当地教师将帮助设计，测试和传播教育材料。传统可穿戴生物传感器的聚合物基底阻碍自由传质，产生剪切应力，导致生物标志物的人为积累或耗尽，并阻碍散热，这是慢性生物医学分析的重大挑战。该CAREER项目旨在推进人工细胞外基质（e-ECM）基板上的软生物电子学，该基板由可拉伸的纳米纤维可拉伸平台组成。所提出的e-ECM生物传感器可以在机械和化学超动力条件下监测离子、代谢物、代谢酶和细胞因子以进行原位实时监测。如果成功，该项目将为长期生物医学传感的可持续和可靠的传感系统实现新的设计规则。该项目的教育目标是通过远程学习生物医学工程制作程序，强调使用坐立不安的玩具的生物医学设备，培养小学生的STEM身份。该方法依赖于开发在线实践项目模块，提供可获取和负担得起的材料，由当地STEM教师的教育研讨会评估模块，并将项目传播到当地和全球社区。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Recent wearable biosensors are built on flat, rigid films. The boundary of these biosensors causes an inflammatory response and inaccurate measurements that challenges long-term use and reliability. This proposal aims to develop a soft, bio-integrated monitoring system that recapitulates the properties of native tissue. The flexible, stretchable, porous, and fiber-based biosensors will be designed and validated to critical biomarker concentrations in real time. The educational aspects of the project will focus on creating science-based toys to understand biomedical engineering fundamentals with inexpensive materials. These will be coupled with new educational modules. Undergraduate students and local teachers will help design, test, and disseminate the educational materials.The polymeric substrates of conventional wearable biosensors impede free mass transfer, create shear stress, cause artificial accumulation or depletion of biomarkers, and block heat dissipation, which is a significant challenge in chronic biomedical analysis. This CAREER project aims to advance soft bioelectronics on the artificial extracellular matrix (e-ECM) substrates that consist of an ultrathin, nanofibrous stretchable platform. The proposed e-ECM biosensors can monitor ions, metabolites, biogases, and cytokines for in situ, real-time monitoring under mechanically and chemically hyperdynamic conditions. If successful, this project will achieve new design rules for sustainable and reliable sensing systems for long-term biomedical sensing. The educational objective of the project is cultivating a STEM identity for elementary students through remote-learning biomedical engineering crafting programs emphasizing biomedical devices using fidget toys. The approach relies on developing online hands-on project modules with accessible and affordable materials, having the modules assessed by educational workshops with local STEM teachers, and disseminating the programs to local and global communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.