I-Corps: Orthopaedic mortars

这个i-Corps项目的更广泛的影响/商业潜力是基于一种脊椎增强系统的开发，该系统可以在手术期间主动防止水泥泄漏，并利用光活化来控制水泥固化和增强脊柱应用的粘附性。它利用紫外线固化技术来控制水泥硬化，从而增强脊椎应用的粘合性能。该系统将结合牙科领域的原理，这些原理已显示出水泥组合物的有利性能和受光管理促进的受控固化能力。这个i-Corps项目寻求开发技术来改善脊椎压缩骨折的治疗。这项技术代表了第一种骨水泥治疗，以防止微创经皮椎体成形术和后凸成形术过程中骨水泥渗漏。骨水泥在椎体强化领域之外有着广泛的应用，包括生长型髋关节和膝关节成形术以及重建正颌手术。这项拟议的技术将用于髋关节和膝关节置换手术。此外，该技术可能适用于颅面重建领域，为该行业提供了新的方法和途径。这项技术适用于已在牙科种植手术中成功使用或独立验证的单体和组件。这项结合的技术可能会建立一种新的治疗方法，减少相邻节段的水泥泄漏和继发性骨折的发生率。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is based on the development of a vertebral augmentation system that actively prevents cement leakage during operations and utilizes photoactivation to control cement curing and enhance adhesion properties for spine applications. It utilizes ultraviolet curing technology to control cement hardening which enhances adhesion properties for spine applications. This system will combine principles from the field of dentistry that have shown advantageous properties for cement compositions and controlled curing capabilities facilitated by light administration. This I-Corps project seeks the development of technology to improve the treatment of vertebral compression fractures. The technology represents the first bone cement treatment to prevent intraoperative bone cement leakage during minimally invasive percutaneous vertebroplasty and kyphoplasty procedures. Bone cement has various applications outside the field of vertebral augmentation, including growing hip and knee arthroplasty and reconstructive orthognathic procedures. The proposed technology will be used for hip and knee arthroplasty procedures. In addition, this technology may be applicable to the field of craniofacial reconstruction providing new methods and approaches for the industry. This technology is adapted with monomers and components that have been utilized successfully in dental implant surgery or independently validated. The combined technology may establish a novel treatment approach that reduces the incidence of cement leakage and secondary fractures at adjacent levels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.