MRI: Track 1 Acquisition of a 400 MHz NMR Spectrometer to Advance Undergraduate Research and Training

该奖项由主要研究仪器项目和化学研究仪器项目共同支持。里德学院正在购买一台配备宽带探头的400 MHz核磁共振光谱仪，以支持米里亚姆·鲍林教授及其同事希瓦尼·阿胡贾和贡萨洛·坎皮洛-阿尔瓦拉多的研究。该仪器促进了合成化学、生物化学和催化领域的研究。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这台仪器加强了里德学院化学系各级学生的教育、研究和教学努力，并通过既定的外展计划增加了高中教师和学生的多样化代表。400 MHz核磁共振波谱仪的获奖旨在加强各级本科生的研究和教育，特别是在机械金属有机催化、金属离子转运蛋白和分子传感器合成等领域。具体地说，该仪器影响了专注于了解铂甲基络合物和双金属Ir-Ru催化剂的合成有机金属化学中的新机理的研究。此外，该仪器还可以表征细菌三磷酸腺苷结合盒转运蛋白的小分子结合体。其他研究包括使用动态晶体框架来表征石化产品的超分子限制，以感应和分离复杂的化学混合物。作为对全球氦供应挑战的回应，这台仪器的收购包括一个具有低损耗低温恒温器的超导磁体，减少了机构的氦消耗。这项奖励反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Reed College is acquiring a 400 MHz NMR spectrometer equipped with a broadband probe to support the research of Professor Miriam Bowring along with colleagues Shivani Ahuja and Gonzalo Campillo-Alvarado. This instrument facilitates research in the areas of synthetic chemistry, biochemistry, and catalysis. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and teaching efforts of students at all levels in the Chemistry Department at Reed College and enables increased diverse representation of high school teachers and students through established outreach programs.The award of the 400 MHz NMR spectrometer is aimed at enhancing undergraduate research and education at all levels, especially in areas such as mechanistic organometallic catalysis, metal ion transporter proteins, and synthesis of molecular sensors. Specifically, the instrument impacts research focused on understanding new mechanisms in synthetic organometallic chemistry of a platinum methyl complex and a bimetallic iridium-ruthenium catalyst. Additionally, the instrument enables the characterization of small molecule binders of bacterial ATP-binding cassette transporter proteins. Other investigations include characterizing the supramolecular confinement of petrochemicals using dynamic crystalline frameworks for sensing and separating complex chemical mixtures. In response to global helium supply challenges, the acquisition of this instrument includes a superconducting magnet with a low loss cryostat reducing the institution’s consumption of helium.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.