MRI: Track 1: Acquisition of a Gas Chromatography-Mass Spectrometer for Advancing Research and Education at Montclair State University

该奖项由主要研究仪器计划和化学研究仪器计划资助。蒙特克莱尔州立大学正在购买一台带有热解装置的气相色谱-质谱联用仪（pygc /MS），以支持Jaclyn Catalano教授及其同事Nathanael Hirscher、Nina Goodey、高金山、吴美银以及该校三个系的另外11名教职员工。该仪器可用于液体和固体样品的常规分离，具有高灵敏度和质量电荷比检测。这种多功能的仪器设置允许不同的样本类型，包括蒙特克莱尔州立大学科学与数学学院的广泛研究和教学需求。该仪器将由不同的本科生和研究生群体进行研究使用。该工具将被纳入七个不同学术专业的课程，每年将有多达300名学生使用，为本科生提供就业所需的基本研究技能和/或为进入专业学校做准备。将建立项目，将仪器纳入大学预科学生外展项目。该奖项旨在使用Py-GC/MS仪器来加强和补充目前正在进行的生物化学、分析、无机、土壤化学和环境科学领域的研究项目。Py-GC/MS是一种多功能仪器，能够分析固体（通过热解）或液体/气体（通过标准注射）相中的化学混合物。这使得该仪器可以被不同部门的不同研究人员用于从土壤到有机化合物的各种样品上。该仪器将加强多个研究项目，包括：(1)发现和开发更特定的无毒药物，这些药物将被特定的酶激活（使其有毒）；(2)利用人工根渗出液启动土壤致癌性和毒性多环芳烃降解的修复策略评价。这一点尤其重要，因为这些毒素在环境中是稳定的，不易降解，通常在环境中持续很长时间；(3)确定合成多糖标准物和自由基标记物的反应中间体，这将有利于开发用于多糖定量和表征的新型自由基标记物；(4)合成和测试新型有机金属催化剂，用于烃类和其他有机底物的反应，由定制的有机配体控制；(5)纽约-新泽西都市圈环境污染物评价及人类海产品消费安全调查。研究结果将用于制定数据驱动的政策建议，以保障人类健康。此外，本科生和研究生将在他们的研究项目和/或学术课程中接受有关仪器的培训。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is funded by the Major Research Instrumentation Program and the Chemistry Research Instrumentation Program. Montclair State University is acquiring a Gas Chromatography-Mass Spectrometer with a pyrolysis unit (Py-GC/MS) to support Professor Jaclyn Catalano and colleagues Nathanael Hirscher, Nina Goodey, Jinshan Gao, Meiyin Wu, and 11 additional faculty members in three departments across the university. This instrument allows for routine separation of liquid and solid samples with high sensitivity and detection of mass to charge ratios. This versatile instrumental setup allows for different sample types encompassing the broad research and teaching needs of the College of Science and Mathematics at Montclair State University. The instrument will be used by the diverse undergraduate and graduate student population performing research. The instrument will be incorporated into coursework pertaining to seven different academic majors and will be used by up to 300 students annually, providing undergraduates with essential research skills for jobs and/or preparing them for professional schools. Programs will be established to include the instrumentation in pre-college student outreach programs.The award is aimed to use the Py-GC/MS instrument to enhance and supplement current ongoing research projects in the fields of biochemistry, analytical, inorganic, and soil chemistry and environmental science. Py-GC/MS is a versatile instrument, capable of analyzing chemical mixtures in the solid (via pyrolysis) or liquid/gas (via standard injection) phase. This allows this instrument to be used by various researchers in different departments on a variety of samples from soils to organic compounds. Multiple research projects will be enhanced by this instrument, including (1) discovery and development of more specific non toxic drugs to be activated (made toxic) by a specific enzyme; (2) evaluation of soil remediation strategies by using artificial root exudate solution to initiate degradation of carcinogenic and toxic polycyclic aromatic hydrocarbons. This is especially important because these toxins are environmentally stable, resistant to degradation, and generally persist in the environment for long periods of time; (3) determination of the reaction intermediates for the synthesis of glycan standards and free radical tags, which will benefit the development of novel free radical tags for glycan quantitation and characterization; (4) synthesizing and testing novel organometallic catalysts for reactions of hydrocarbons and other organic substrates, controlled by tailored organic ligands; (5) assessment of the environmental contaminants in the New York-New Jersey metropolitan area and to investigate human seafood consumption safety. The results will be used to formulate data-driven policy recommendations to safeguard human health. In addition, undergraduates and graduate students will be trained on the instrument as part of their research projects and/or academic coursework.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.