SBIR Phase I: Sprayable hydrogel sealant for gastrointestinal wound protection

这个小型企业创新研究(SBIR)第一阶段项目的更广泛影响/商业潜力集中在改进内窥镜和机器人手术等微创程序中的伤口闭合方法。通过利用基于生物兼容、生物可降解聚合物的创新水凝胶技术，该项目旨在建立一种针对手术伤口和穿孔的弹性屏障。这种变革性的方法，没有繁琐的金属夹，有望避免延迟出血、穿孔、感染和术后并发症。该技术最初是为胃肠道设计的，迎合了未得到满足的临床需求，扩展到心血管和肺密封方面的应用。社会影响明显体现在患者预后的改善和医疗成本的降低，而商业潜力包括广泛采用一种卓越的伤口闭合解决方案。这个小型企业创新研究(SBIR)第一阶段项目专注于开发一种多功能、可喷雾的密封剂套件，为胃肠道伤口提供长期保护。该技术采用多种黏附机制，可确保生物表面的持续黏附。通过导管输送，它与商业内窥镜和微创设备无缝集成，优化了手术流程。项目目标包括改进粘合剂配方以满足胃肠道要求和严格的比较测试。预期的技术成果包括提高手术效率、降低并发症发生率和改善伤口愈合，将这一创新定位为微创手术领域的变革力量。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project centers on improving wound closure methods in minimally invasive procedures, such as endoscopy and robotic surgery. By harnessing innovative hydrogel technology based on biocompatible, biodegradable polymers, this project aims to establish a resilient barrier over surgical wounds and perforations. This transformative approach, devoid of cumbersome metal clips, promises to avert delayed bleeding, perforations, infections, and post-procedural complications. Initially designed for the gastrointestinal tract, the technology caters to unmet clinical needs, extending to applications in cardiovascular and lung sealing. The societal impact is evident in improved patient outcomes and reduced healthcare costs, while the commercial potential includes widespread adoption of a superior wound closure solution.This Small Business Innovation Research (SBIR) Phase I project focuses on the development of a versatile, sprayable sealant kit that delivers prolonged protection for gastrointestinal wounds. Employing multiple adhesion mechanisms, the technology ensures sustained adhesion across biological surfaces. Delivered via a catheter, it seamlessly integrates with commercial endoscopes and minimally invasive devices, optimizing surgical workflow. The project objectives involve the refinement of the adhesive formulation to meet gastrointestinal requirements and rigorous comparative testing. Anticipated technical outcomes encompass enhanced procedure efficiency, reduced complication rates, and improved wound healing, positioning this innovation as a transformative force in minimally invasive surgery.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.