Understand and reshape the impact of “aged” adaptive immunity and type 2 diabetes/obesity on fracture healing

免疫细胞对于再生的开始和成功完成该过程至关重要。平衡的适应性免疫应答是再生级联中的决定性因素，免疫调节策略代表了增强愈合的新治疗方法。尽管骨免疫学的研究取得了显著进展，但获得性免疫往往被忽视。在这里，我们将研究适应性免疫在老年患者（肥胖/糖尿病）再生过程中的影响，制定一项策略，以分散不利的免疫细胞参与愈合的早期炎症反应，并分析T细胞对胶原蛋白1沉积和成骨祖细胞分布的影响在骨痂形成过程中骨愈合的情况。与研究单位的其他项目密切合作，还将分析适应性免疫细胞对细胞衰老，成脂干细胞分化和血管重建的影响。

Immune cells are essential for the onset of regeneration and for the successful completion of the process. A balanced adaptive immune response is a deciding factor in the regenerative cascade and immune modulatory strategies represent a new therapeutic approach to enhance healing. Even though the osteo-immunological research has progressed remarkably, the adaptive immunity is often not considered. Here, we will study the influence of the adaptive immunity in regenerative processes of elderly compromised patients (obese/ diabetic), develop a strategy to distract unfavourable immune cells from partaking in the early inflammatory reaction of healing, and analyse the influence of T cells on the collagen 1 deposition and osteogenic progenitor cell distribution during callus formation in bone healing situations. In close cooperation with other projects of the Research Unit the influence of adaptive immune cells on cellular senescence, adipogenic stem cell differentiation, and revascularisation will also be analyzed.