Nutrition, aging and marrow adipose tissue in bone maintenance and regeneration

富含脂肪细胞的黄色骨髓在衰老和肥胖以及其他代谢紊乱过程中发展。它被认为有助于功能失调的骨稳态和减弱骨组织修复。同时，衰老和肥胖伴随着低度全身性炎症（“炎症-衰老”）和局部脂肪细胞释放细胞因子。这两个因素是众所周知的骨愈合的负调节因子。本研究的目的是探讨骨髓脂肪形成的调控机制及其对骨组织修复的调控作用。据推测，不同的生理刺激，如饮食组成和不同的免疫细胞类型，促进潜在的有益和/或病理类型的骨髓驻留脂肪细胞的积累。骨髓脂肪组织与骨质量降低和骨愈合受损的潜在关联及其在肥胖和老年个体中的优先发生强调了进一步研究代谢病理学和骨再生的关系的必要性。

Adipocyte-enriched yellow bone marrow develops during aging and obesity, among other metabolic disorders. It is thought to contribute to dysfunctional bone homeostasis and attenuated bone tissue repair. At the same time, aging and obesity are accompanied by a low-grade systemic inflammation (‘Inflamm-Aging’) and release of cytokines by local adipocytic cells. Together, these two factors are well-known negative regulators of bone healing. The aim of this project is to investigate the regulatory mechanisms driving marrow adipogenesis and its regulation of bone tissue repair. It is hypothesized that different physiological stimuli, such as diet-composition and different immune cell types, promote the accumulation of potentially beneficial and/or pathological types of marrow-resident adipocytes. The potential association of marrow-adipose tissue with reduced bone quality and impaired bone healing and its preferential occurrence in obese and aged individuals emphasizes the necessity to further investigate the relationship of metabolic pathologies and bone regeneration.