Selective photooxygenations and oxidative C−H-functionalizations of indole alkaloids and polycyclic terpenes through quinone photoorganocatalysis

本项目的目标是将催化光氧化和光氧化应用于四氢咔唑、四氢β-咔啉、单萜烯吲哚生物碱以及白桦树皮中的可再生化学物质白桦醇的新的选择性转化。在苯二酮类有机光催化领域的开创性研究使我们能够指导选择和优化合适的催化剂和助催化剂，以确定根据所研究的不同底物类别调整的反应条件。将传统实验装置中的光氧化反应与连续流动反应器相结合，实现了液、气相之间的有效传质，实现了快速、可重复的反应优化，并实现了高合成产率。

The objective of this project is the application of catalytic photooxidations and photooxygenations to new selective transformations of tetrahydrocarbazoles, tetrahydro-β-carbolines, monoterpene indole alkaloids as well as betulin, a renewable chemical from the bark of the birch tree. Seminal previous investigations in the area of organic photocatalysis with quinones enable the guided selection and optimization of suitable catalysts and co-catalysts, to identify reaction conditions which are adjusted to the respective substrate classes investigated. The combination of photooxygenation reactions in conventional experimental setups with continuous flow reactors, which allow an efficient mass transfer between liquid and gas phase, enables accelerated and reproducible reaction optimization and the realization of high synthetic yields.