Intracellular Communication of Gliomas via Exosomes

恶性胶质瘤逃避治疗是因为其复杂和适应性的细胞组成，它们通过代偿机制逃避大多数治疗的能力以及药物递送的困难。作为对肿瘤内细胞通讯和信号传导机制的补充，细胞外囊泡（EVs）已被确定为细胞间信号分子的转运体，微rna已被确定为这些细胞外囊泡的关键内容。几位研究人员最近的数据表明，将选定的mir引入肿瘤细胞可以影响它们的生长、增殖、干性和放射抗性。概述的项目旨在深入分析EV通过微rna信号介导的细胞表型和功能适应的调节。目标是开发基于EV技术和miR药理学的胶质母细胞瘤新疗法的策略。

Malignant gliomas evade therapy because of their complex and adaptive cellular composition, their ability to evade most therapies through compensatory mechanisms and the difficulty to deliver drugs.Complementing the mechanistic understanding of intratumoural cellular communication and signaling, extracellular vesicles (EVs) have been identified as transporters of signaling molecules between cells and micro-RNAs have been identified as a key content of these EVs. Recent data from several investigators have shown that the introduction of selected miRs into tumor cells can affect their growth, proliferation, stemness and radio-resistance.The outlined project aims to contribute to the in depth analysis EV mediated modulation of cellular phenotypes and functional adaptation via micro-RNA signaling. The goal is to develop strategies based on EV technology and miR pharmacology for novel therapies against glioblastoma.