Central Project 1 (Cologne Experimental Eye Imaging Center (CEE-IC))

拟议的研究联盟的中心目标是识别和分析眼部疾病的炎症相关机制。随着所有项目研究炎症的细胞过程，特别是非侵入性或微创的活体成像技术是必要的，它可以实时捕捉和跟踪体外和体内实验中诱导的变化。CEE-IC将提供一个实验成像设施，配备不同的OCT和荧光血管成像设备，以及立体显微镜，使目标结构的最先进检查成为可能，而不会因组织探测或光毒效应而篡改结果。此外，C1-项目将提供成熟的先进容器和颗粒分析方法，并将与个别项目密切合作，进一步开发标准化、高质量的数据分析方法。因此，将产生高度可靠和创新的数据集。

The central aim of the proposed research consortium is the identification and analysis of inflammation-associated mechanisms of ocular diseases. As all projects investigate cellular processes of inflammation in particular non- or minimally-invasive intravital imaging techniques are necessary, which in real time can capture and follow up the induced alterations both in in vitro and in vivo experiments. The CEE-IC will provide an experimental imaging facility equipped with different OCT and fluorescence angiography devices together with stereomicroscopy that will enable state-of-the-art examination of the target structures without tampering the results by tissue probing or phototoxic effects. Furthermore the C1-project will provide well-established advanced vessel and particle analysis methods and will develop further standardized, highly qualitative data analysis methods in close cooperation with the individual projects. Thereby highly reliable and innovative data sets will be generated.