Mitochondrial morphology regulation by dynamic Bcl-2 protein complexes (P26*)

应力诱导的线粒体损伤受融合和裂变的限制，线粒体从碎片化的囊泡到高灌注的网络。线粒体形态和清除的快速可逆变化表明了动态控制过程，但线粒体质量控制是如何协调的，尚不清楚。拟议的项目将利用稳定的Bcl-2蛋白构象和定量共聚焦显微镜技术来探索线粒体形态和Bcl-2蛋白对清除的控制。我们旨在建立Bcl-2蛋白可逆构象变化与线粒体动力学调控耦合的新概念。

Stress-induced mitochondrial damage is confined by fusion and fission evershifting mitochondria from fragmented vesicles to hyperfused networks. Swift and reversible changes of mitochondrial morphology and clearance indicate dynamic control processes, but how mitochondrial quality control is coordinated, remains unknown. The proposed project will explore mitochondrial morphology and clearance control by Bcl-2 proteins using stabilized Bcl-2 protein conformations and quantitative confocal microscopy techniques. We aim to establish a new concept of coupling reversible conformational changes of Bcl-2 proteins to mitochondrial dynamics regulation.