Mechanisms of controlled gene expression in cells and organisms.

这个项目的目标是揭示一种对所有真核细胞中的基因表达有重大影响的细胞机制的本质。如何控制基因表达对所有生命形式都是至关重要的。该项目计划开发分子工具，使人们能够在活细胞、组织和整个生物体中可视化和询问这种基因调控机制。这些结果有望导致对细胞如何通过协调基因表达的变化来对生理和环境提示做出反应的基本理解，并为出于制药、农业和生物技术目的的操纵提供潜在的途径。

The goal of this project is to reveal the nature of a cellular mechanism that has a major influence on gene expression in all eukaryotic cells. How gene expression is controlled is of fundamental importance to all life forms. The project plans to develop molecular tools that enable the visualisation and interrogation of this gene regulatory mechanism in live cells, tissues and whole organisms. The outcomes are anticipated to lead to an essential understanding of how cells respond to physiological and environmental cues by coordinating changes in gene expression, and to provide potential avenues towards manipulation for pharmaceutical, agricultural and biotechnology purposes.