Effects of virtual reality in the augmentation of neuronal network plasticity (C07)

上一个资助期的一个主要发现是，对视频游戏干预的反应，海马体-前额叶网络中的大脑可塑性效应主要是由要求空间导航(训练同一个视频游戏的3D和2D版本)引起的。精神分裂症患者的临床数据显示，在3D训练条件下，一般精神病理学明显下降。基于这一令人鼓舞的证据，我们下一个资助期的目标是(1)通过在游戏中使用虚拟现实技术来最大化可塑性效应，(2)揭示网络可塑性效应的时间过程和序列，以及(3)在训练之前寻找功能连通性测量中长期可塑性的预测因子。

A main finding of the previous funding period was that brain-plasticity effects in the hippocampal-prefrontal network in response to a video game intervention are primarily induced by demanding spatial navigation (training of a 3D versus 2D version of the same video game). Clinical data of schizophrenia patients show a significant decrease in general psychopathology in the 3D training condition. Based on this encouraging evidence our goal for the next funding period is to (1) maximize the plasticity effects by using virtual-reality technology in the game, (2) unravel the time course and sequence of network plasticity effects and (3) to search for predictors of long-term plasticity in functional connectivity measures prior to training.