Cognitive and motor networks as a basis of mobility in patients with Parkinson´s disease (C08)

该项目的目的是推进认知和运动神经元回路功能连接的多尺度评估，以实现与帕金森病患者移动性、驾驶和步行相关的日常任务。术中和术后神经网络活动的记录将在现实条件下进行，结合驾驶模拟器设置，虚拟现实，移动的EEG，可穿戴运动跟踪传感器和眼动跟踪技术。将通过应用脑深部刺激的新算法（例如模式化刺激）进行网络活动的调制，并评估其对行为表现的影响和重塑的皮质下-皮质网络活动的评估。

The aim of this project is to advance multi-scale assessments of functional connectivity of cognitive and motor neuronal circuits to daily relevant tasks related to mobility in Parkinson´s disease patients, driving and walking. Intraoperative and postoperative recordings of neuronal network activities will be performed under realistic conditions, combining a driving simulator setup, virtual reality, mobile EEG, wearable movement-tracking sensors and eye-tracking techniques. Modulation of network activities will be performed by applying novel algorithms of deep brain stimulation such as patterned stimulation with evaluation of its impact on behavioral performance and assessment of reshaped subcortico-cortical network activity.