Bodipy-tagged ligands for transition metal complexes

该项目的总体目标是利用生物化学和分子生物学中建立良好的基于荧光的方法，用于有机金属化学和均相催化中的新应用，旨在阐明机理步骤。这需要合成Bodipy-荧光团标记的有机金属配合物。从各个受激络合物发出的荧光应提供关于金属络合物和关于化学反应后配位层特征变化的信息，设想了三个分项目：a）Crabtree型催化剂与氢的荧光反应; B）在活性物质的分解或失活反应后，观察到用互补荧光团标记的双核金属络合物的形成在均相催化期间; c）通过再次使用互补荧光团标记的离子，观察阳离子有机金属络合物和相应阴离子的离子配对。互补意味着利用两种不同的荧光团，其在紧密空间关联时形成FRET对。因此，仅当满足该条件时才观察到FRET信号，并且该FRET信号然后提供关于成对形成反应的直接信息。

The overall target of this project is to utilize fluorescence-based methods, which are well established in biochemistry and molecular biology, for new applications in organometallic chemistry and in homogeneous catalysis aiming for the elucidation of mechanistic steps. This requires the synthesis of Bodipy-fluorophore tagged organometallic complexes. The fluorescence light emitted from the respective excited complexes should provide information on the metal complexes and on characteristic changes in the coordination sphere following chemical reactions.Three sub-projects are envisaged: a) fluorogenic reactions of Crabtree-type catalysts with hydrogen; b) the observation of the formation of dinuclear metal complexes tagged with complementary fluorophores following decomposition or deactivation reactions of the active species during homogeneous catalysis; c) the observation of ion pairing of cationic organometallic complexes and the respective anions by again using complementary fluorophore tagged ions. Complementary means that two different fluorophores are utilized, which form a FRET-pair upon close spatial association. Consequently, a FRET-signal is only observed when this condition is met and this FRET-signal then provides direct information on pair-formation reactions.