Functional characterization of Rasal1 in the signal transduction of plexins

丛状蛋白由一系列跨膜蛋白组成，它们是信号素的受体。它们在许多生理和病理生理过程中起着决定性的作用，例如在免疫系统、骨骼系统和癌症中。丛状蛋白的信号转导途径仍然知之甚少。特别是，丛蛋白调节RAS GTP酶活性的分子机制在很大程度上还不清楚。本研究的目的是研究RasGAP蛋白Rasal1在丛状蛋白信号转导中的作用，并分析其在小鼠体内和体外的功能相关性。

Plexins comprise a family of transmembrane proteins, which serve as receptors for semaphorins. They play decisive roles in a multitude of physiological and pathophysiological processes, e.g. in the immune system, the bone system and in cancer. The signal transduction pathways of plexins remain poorly understood. In particular, the molecular mechanism through which plexins regulate the activity of Ras GTPases is largely unclear. The aim of this proposal is to characterize the role of the RasGAP protein Rasal1 for the signal transduction of plexins, and to analyze its functional relevance in vitro and in vivo in mice.