Autophagy in ribosome biogenesis and quality control (D06 (B01)+)

这个项目遵循这样的想法，即过早或有缺陷的前核糖体和在核糖体生物发生过程中产生的核糖体通过一种称为核吞噬的专门的选择性自噬途径来清除。我们的目标是剖析噬核体的调控原理，并确定不同的噬核体清除途径中涉及的选择性因素。此外，我们的目的是分析核噬菌体在急性髓系白血病(AML)发病机制中的可能影响。

This project follows the idea that premature or defective pre-ribosomes and ribosomes that are generated in the course of ribosome biogenesis are cleared by a specialized selective autophagy pathway termed ribophagy. We aim to dissect the regulatory principles of ribophagy and to identify the selectivity factors involved in distinct ribophagic clearance pathways. Moreover, we aim to analyze the possible impact of ribophagy on pathogenesis of acute myeloid leukemia (AML).