Design of antibacterial inorganic nanostructured surfaces by combinatorial glancing angle deposition of sacrificial anode nanocolumns

该联合项目旨在设计，开发和评估具有结构和化学功能的新型抗菌无机纳米结构表面。在路德维希教授的小组中，纳米柱状表面将通过组合掠射角沉积（Combi-GLAD）来制造。Ti基或Ta基纳米柱的形态（例如尖端形状）和化学组成（例如用牺牲阳极元件如Au/Ag装饰）将被定制以实现有效的抗菌功能。在Köller教授的团队中，将研究纳米结构表面的抗菌效果以及组织细胞相容性。结果将一起讨论，以改善在下一个优化周期的表面的设计和制造。创新的材料设计过程将导致优化的表面，其显示出自限性和有效的抗菌活性以及足够的组织细胞相容性。优化的表面可用于未来的植入物和医疗器械。

This joint project aims at the design, development and evaluation of novel antibacterial inorganic nanostructured surfaces with combined structural and chemical functionality. In the group of Prof. Ludwig nanocolumnar surfaces will be fabricated by combinatorial glancing angle deposition (Combi-GLAD). The morphology (e.g. tip shape) and chemical composition (e.g. decoration with sacrificial anode elements like Au/Ag) of the Ti- or Ta-based nanocolumns will be tailored to achieve efficient antibacterial functionality. In the group of Prof. Köller, the antibacterial effects as well as tissue cell compatibility of the nanostructured surfaces will be studied. The results will be discussed together in order to improve the design and fabrication of the surfaces in the next optimization cycle. The innovative material design process shall lead to an optimized surface, which shows a self-limited and effective antibacterial activity as well as sufficient tissue cell compatibility. An optimized surface could be used in future implants and medical devices.