RadioGenes2: Modelling complex biomolecular interactions in radiated tumours: Towards understanding the genesis of therapeutic radioresistance.

大约45%的膀胱癌患者需要放疗或手术。放疗的失败率约为50%。手术（膀胱切除）大大降低了生活质量。模拟放射癌细胞中复杂的基因相互作用将为肿瘤放射治疗耐药的分子成因提供重要的知识。我们的发现将提供：(i)诊断放射敏感性的精确数学/计算模型；（ii）可应用于制药业的进一步见解，例如发现有可能提高放射治疗成功率的新分子靶点；（iii）适用于更多种类肿瘤的整体建模技术。

About 45% of bladder cancer patients require radiotherapy or surgery. Radiotherapy has a failure rate of ~50%. Surgery (bladder removal) diminishes quality of life considerably. Modelling complex gene interactions in radiated cancer cells will provide crucial knowledge on the molecular genesis of radiotherapy-resistance of tumours. Our findings will provide: (i) an accurate mathematical/computational model for diagnosing radiosensitivity; (ii) further insights to be applied in the pharmaceutical sector such as the discovery of novel molecular targets that have the potential to increase radiotherapy success ratios; (iii) a holistic modelling technique applicable to a larger diversity of tumours.