Role of platelets in control and clearance of hepatitis B virus infection via modulation of liver tissue environment and metabolism (06)

含有不同实质和非实质肝细胞以及肝脏代谢组的肝脏微环境在肝脏病毒感染的清除中起关键作用。在此，我们研究了在病毒感染的情况下，血小板在塑造肝脏微环境、极化免疫细胞表型和影响肝脏代谢方面的直接和间接作用。我们分析血小板如何促进肝脏免疫生态位的重塑，它们如何在抗病毒治疗的背景下与肝细胞直接相互作用，以及它们如何影响清除机制。我们的数据可能暗示了新的靶点，用于支持肝病毒感染背景下有效和持久的抗病毒反应，并减少不必要的免疫介导的副作用。

The liver microenvironment containing different parenchymal and non-parenchymal liver cells and the hepatic metabolome play a pivotal role in the clearance of hepatic virus infections. Here we investigate the direct and indirect role of platelets in shaping the liver microenvironment, polarizing immune cell phenotypes and affecting liver metabolism in the context of viral infections. We analyse how platelets contribute to the reshaping of the liver immune niche, how they interact directly with hepatocytes in the context of antiviral therapies and how they affect clearance mechanisms. Our data might hint at novel targets used to support effective and long-lasting antiviral responses in the context of hepatic viral infections and reducing unwanted, immune-mediated side-effects.