Effects of unilateral temporal lobe resections on the cerebral processing of emotionally negative visual stimuli

本研究旨在探讨单侧颞叶切除术对视觉呈现的负面和中性图片、面孔和文字的感知和记忆的影响。切除包括杏仁核、海马和周围结构（AH+）或杏仁核和部分前颞叶，保留海马（AAT+）。在电生理学上，我们研究了这种切除术在多大程度上降低了EEG的情绪敏感事件相关电位（ERP）。2)这种减少是半球特异性的或特定于某些刺激类型。3)AH+和AAT+组之间存在差异。与此同时，我们利用功能性磁共振成像（fMRI）检测了颞叶切除术后在感知和记忆情绪刺激时血流动力学反应的变化。5)调查是否有任何影响是刺激或半球特异性的。6)AH+和AAT+组的激活模式不同。总之，结果将提供因果关系的证据杏仁核和周围结构的作用，在情感刺激处理。

This project investigates effects of unilateral temporal lobe resections on the perception of and memory for visually presented emotionally negative and neutral pictures, faces, and words. Resections comprise either amygdala, hippocampus, and surrounding structures (AH+) or the amygdala and parts of the anterior temporal lobe, sparing the hippocampus (AAT+). Electrophysiologically, we investigate the extent to which such resections 1) reduce emotion-sensitive event-related potentials (ERPs) of the EEG. 2) Such reductions are hemisphere-specific or specific to certain stimulus types. 3) Differences exist between the AH+ and AAT+ groups. In parallel, using functional magnetic resonance imaging (fMRI), we test for 4) changes in hemodynamic responses during perception of and memory for emotional stimuli following temporal lobe resections. 5) Investigate whether any effects are stimulus- or hemisphere-specific. 6) AH+ and AAT+ groups differ in their activation patterns. Together, results will provide causal evidence regarding the role of amygdala and surrounding structures in affective stimulus processing.