Fundamental investigations on the effect of high effective ion temperatures on the ion mobility, cluster formation, dissociation and their dynamics as well as fragmentation by high-resolution, high kinetic energy Ion mobility spectrometry

该项目及其关于高有效离子温度对离子迁移率、簇形成、解离及其动力学以及碎裂的影响的基本问题，旨在作为该项目的后续延续（标志已删除）。与此同时，所请求的继续是对正在进行的超高分辨率离子迁移率光谱法项目（去除符号）的极好补充，该项目用于检测离子迁移率中甚至最小的差异。然而，由于中离子迁移谱仪的完全不同的设计（去除符号），这仅可能用于低于10 Td的低降低电场强度。因此，计划继续进行的高能离子迁移谱仪（HiKE-IMS）研究无法在（符号已删除）中进行，该研究主要集中在单体和二聚体的补充研究，特别是异构体和对映体的分离。与此相反，这个延续的重点是详细的实验研究离子和漂移气体分子质量和有效离子温度对离子迁移率，簇的形成，簇的解离和它们的动力学以及碎片，这是唯一可能与HiKE-IMS的效果。在这种情况下，在恒定的有效离子温度下的离子迁移率的绝对温度和减少的电场强度的效果也将被调查。基本问题是，尽管有效离子温度恒定，但是否存在不同的离子迁移率。此外，将直接测量不同离子的离子迁移率作为恒定绝对温度下的减小的电场强度的函数，这也只有HiKE-IMS才有可能。这些所谓的α函数，然后进行比较的α函数计算的测量数据的场不对称离子迁移谱仪（FAIMS），以调查集群过渡的动力学。对于所有计划的实验研究，所需的仪器将在继续开发。基于的发现（去除符号），将开发一种新的HiKE-IMS，其分辨率高达200，温度稳定性高达120 °C。这包括一个新的漂移管设计，一个新的离子门控序列和一个受控的电晕放电源，以及先进的电子产品的发展。为了在高达120 Td的较宽范围的降低的电场强度上比较α函数，FAIMS（去除符号）还需要显著改进的控制电子设备，这也将被开发。

This project with its fundamental questions on the effect of high effective ion temperatures on the ion mobility, cluster formation, dissociation and their dynamics as well as fragmentation is intended as a consequent continuation of the Project (sign removed). At the same time, the requested continuation is an excellent complement to the ongoing Project(sign removed)on ultra-high resolution ion mobility spectrometry for the detection of even smallest differences in ion mobility. However, due to the completely different design of the ion mobility spectrometer in(sign removed), this is only possible for low reduced electric field strengths below 10 Td. Thus, the investigations with a high-energy ion mobility spectrometer (HiKE-IMS) planned in the continuation are not possible in(sign removed), which mainly concentrates on complementary investigations on monomers and dimers and in particular on the separation of isomers and enantiomers. In contrast, the focus of this continuation is on detailed experimental investigations on the effect of ion and drift gas molecular mass and effective ion temperature on the ion mobility, cluster formation, cluster dissociation and their dynamics as well as fragmentation, which are only possible with HiKE-IMS. In this context, the effect of absolute temperature and reduced electric field strength on the ion mobility at constant effective ion temperature will be also investigated. The fundamental question is whether different ion mobilities exist despite constant effective ion temperature. Furthermore, the ion mobility of different ions as a function of the reduced electric field strength at constant absolute temperature will be directly measured, which is also only possible with HiKE-IMS. These so-called alpha functions are then to be compared with the alpha functions calculated from the measurement data of a Field Asymmetric Ion Mobility Spectrometer (FAIMS) in order to investigate the dynamics of cluster transitions. For all planned experimental investigations, the required instrumentation will be developed in the continuation. Based on the findings of(sign removed), a new HiKE-IMS with a significantly higher resolving power up to 200 and a temperature stability up to 120 °C will be developed. This includes a new drift tube design, a new ion gating sequence and a controlled corona discharge source as well as the development of advanced electronics. In order to compare the alpha functions over a wide range of reduced electric field strengths up to 120 Td, the FAIMS from(sign removed)also requires significantly improved control electronics, which will be also developed.