Lipid signaling by anandamide and the bliss of resilience: genetic models at cellular and neural-network levels (B04)

B04将研究anandamide信号在恢复力中的作用。Anandamide是一种内源性大麻素和大麻素CR1受体的配体，涉及恐惧消退，焦虑缓解和HPA轴下调。预计在应激源暴露时，大麻素信号传导通过其对神经元兴奋性以及大规模网络功能的影响来促进应激反应调节。B04将在应激暴露期间的精确时间点在遗传上增强网络中选定神经元的anandamide信号传导，并研究其对兴奋性，网络功能和弹性的影响。

B04 will investigate the role of anandamide signaling in resilience. Anandamide is an endocannabinoid and ligand of the cannabinoid CR1 receptor, implicated in fear extinction, relief from anxiety and HPA axis down-regulation. It is expected that anandamide signaling at the time of stressor exposure facilitates stress response regulation by its effects on neuronal excitability as well as large-scale network function. B04 will genetically enhance anandamide signaling at precise time points during stressor exposure in selected neurons of the network and investigate its effect on excitability, network function, and resilience.