Regulation of neural excitability and neural-network function in resilience - a multimodal and (back-) translational approach (B05)

在人类背内侧前额叶皮层（作为探针）上使用神经导航经颅磁刺激结合同步EEG（作为读出），B 05将确定该皮层区域的兴奋性和皮质-皮质功能连接，追求差异恐惧条件反射和兴奋性变化期间的适应性应激反应与不同的功能皮层连接特征和弹性结果相关的假设。在小鼠和人类中，B5将进行最先进的功能连接测量，并将人类刺激激活范例反向翻译到小鼠。最后，将开发因果光遗传学操作。

Using neuronavigated transcranial magnetic stimulation over human dorsomedial prefrontal cortex (as a probe) in combination with simultaneous EEG (as a read-out), B05 will determine the excitability and cortico-cortical functional connectivity of this cortex area, pursuing the hypothesis that adaptive stress response during differential fear conditioning and excitability changes are linked to distinct functional cortical connectivity signatures and resilient outcome. Both, in mice and humans, B5 will conduct state-of-the-art functional connectivity measures, and a back-translation of human stimulus activation paradigms to the mouse. Finally, causal optogenetic manipulations will be developed.