Tertiary amines with very high steric congestion

位阻胺在有机合成中起着重要的作用，例如，作为低亲核性的碱。它们用于制备各种其他产品，例如自旋标签化合物。空间位阻胺作为光稳定剂在高分子材料中的应用也具有重要的定量意义。在基础研究中，结构的特殊特征，如三异丙胺金字塔结构的扁平程度，被深入研究和有争议的讨论。具有明显更高位阻的简单三烷基胺，如三叔丁胺，是未知的，应该在项目内首次通过九种不同的合成方法制备。新产物必须从单晶的堆积和分子结构以及溶液中的构象平衡（动态核磁共振光谱和15N核磁共振）的角度进行分析。我们认为，到目前为止，这些叔胺的位阻充血被低估了。因此，出乎意料的高反应性，例如，在容易发生裂解成仲胺和烯烃，将是后果。

Sterically hindered amines play an important part in organic synthesis, for example, as bases with low nucleophilicity. They are utilized to prepare a variety of other products, for instance, spin-label compounds. The application of sterically hindered amines as light stabilizers in polymeric materials is also quantitatively of great importance. In basic research, special features of structures, such as the degree of flattening in the pyramidal structure of triisopropylamine, were intensively investigated and controversially discussed. Simple trialkylamines with significantly higher steric hindrance, for example, tri-tert-butylamine, are unknown and should be prepared within the project via nine different methods of synthesis for the first time. The novel products have to be analyzed in view of the packing and molecular structures in single crystals and in connection with conformational equilibria in solution (dynamic NMR spectroscopy and 15N NMR). We assume that the steric congestion in these tertiary amines has been underestimated up to now. Therefore, an unexpectedly high reactivity, for instance, in the easily occurring cleavage into a secondary amine and an alkene, will be the consequence.