Mechanisms of generation and maintenance of immune tolerance in pregnancy

迫切需要更好地理解胚泡成功着床及其随后在母体子宫中生长的复杂机制。了解病理生理机制参与妊娠障碍的发展是必不可少的，以制定新的战略，其预防和治疗。着床是决定妊娠成功的早期事件。胚胎着床失败和延迟着床对人类生殖都有致命的后果，研究支持这一重要事件的机制具有根本的重要性。加入这一建议的科学家是怀孕免疫学领域的专家，他们的出版物记录了这一点。临床医生和基础研究的跨学科网络及其在胎儿-母体界面植入期间发生的特定细胞或过程的专业化将加强创新战略的开发和推广，这将有助于克服生殖医学领域目前面临的问题。本科学网络的重要性在于建立和支持各小组之间的强有力互动，目的是加强合作，促成合作出版物，并支持初级和高级科学家的合并。长期目标是资助一个合作网络，例如研究小组，以便能够在长期多中心努力中研究这一重要课题，从而显著改善妊娠障碍的预防、早期发现、诊断、治疗和干预后治疗。

A better comprehension of the complex mechanisms underlying the successful implantation of the blastocyst and its subsequent growth in the maternal womb is urgently needed. Understanding pathophysiologic mechanisms involved in the development of pregnancy disorders is essential to develop new strategies for their prevention and treatment. Implantation is an early event that defines pregnancy success. Implantation failure and delayed implantation both have fatal consequences for human reproduction and the study of the mechanisms supporting this important event is of fundamental importance. Scientists that join this proposal are experts in the field of immunology of pregnancy as documented by their publication tracks. The interdisciplinary network of clinicians and basic researches and their specialization in particular cells or processes taking place during implantation at the feto-maternal interface will enhance the development and promotion of innovative strategies that will help overcoming current problems faced in the field of reproductive medicine. The significance of the present scientific network is to establish and support strong interactions between the groups with the aim to strengthen cooperation resulting in collaborative publications and to support the consolidation of junior and senior scientists. The long-term aim is to fund a cooperation network, e.g. a Forschergruppe, that will allow to study this important topic in a long-term multi-center effort to significantly improve the prevention, early detection, diagnosis, therapy and post-intervention treatment of pregnancy disorders.