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Mentorship in Biobehavioral Mechanisms of Avoidant/Restrictive Food Intake Disorder

回避/限制性食物摄入障碍的生物行为机制的指导

基本信息

批准号：
10783916
负责人：
JENNIFER JOANNE THOMAS
金额：
$ 18.69万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-05 至 2028-08-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10783916
关键词：
Adult Affect Amygdaloid structure Anisotropy Authorship Award Behavior Therapy Body Weight decreased Brain Brain imaging Child Choking Chronic Clinical Clinical Research Clinical Trials Design Corticospinal Tracts Cues Data Dedications Dependence Diffusion Magnetic Resonance Imaging Discipline Doctor of Philosophy Eating Disorders Ecological momentary assessment Environment Etiology Food Foundations Fright Functional Magnetic Resonance Imaging Functional disorder Funding Future General Hospitals Goals Grant Hormones Hunger Hyperactivity Hypothalamic structure Impairment Incubators Infrastructure Institution Interdisciplinary Study Laboratories Leadership Link Maintenance Malnutrition Maps Massachusetts Mentors Mentorship Mid-Career Clinical Scientist Award (K24)National Institute of Mental Health Negative Valence Neurobiology Neurocognitive Deficit Neurosecretory Systems Paper Pathway interactions Patient Care Pattern Perception Phenotype Psychiatry Psychology Publications Publishing Research Research Domain Criteria Research Personnel Resources Sensory Disorders Somatosensory Cortex Strategic Planning Structure Symptoms Taste Perception Techniques Texture Time Training Vomiting Weight avoidant restrictive food intake disorder biobehavior brain abnormalities career career development dietary supplements digital mental health early satiety experience feeding food avoidance food restriction functional disability gray matter innovation interest median forebrain bundle medical schools mid-career faculty multidisciplinary multimodal neuroimaging multimodality neuromechanism next generation novel patient oriented research programs psychosocial response restrictive eating skills stria terminalis white matter

项目摘要

PROJECT SUMMARY/ABSTRACT The applicant, Jennifer J. Thomas, Ph.D., is the Co-Director of the Eating Disorders Clinical and Research Program at Massachusetts General Hospital and Associate Professor of Psychiatry at Harvard Medical School. Over the last decade Dr. Thomas’s research has focused on the pathophysiology and treatment of feeding and eating disorders, particularly the newly recognized avoidant/restrictive food intake disorder (ARFID). Her successful mentoring experience, publication record, and current funding demonstrate her commitment and passion for patient-oriented research and provide an excellent foundation to accomplish the goals and objectives of the proposed K24 Award. Dr. Thomas’s career development goals will enable her to (1) deepen her expertise in multimodal neuroimaging techniques (integrating structural, functional, and diffusion MRI) to enhance her multidisciplinary collaborations and ability to provide translational mentorship; (2) create a sustainable infrastructure for continued research mentorship of diverse scholars to develop their own unique expertise within ARFID that will extend beyond her laboratory and beyond the K24 period; and (3) bring together her two lines of research (on behavioral treatment of ARFID and neurobiology of ARFID) to develop new treatments that modify target neural mechanisms using advanced clinical trial designs. The proposed award will enable Dr. Thomas to redistribute her effort to 30% mentorship; 60% research; and 10% patient care. Dr. Thomas will further establish a patient-oriented research program that uses innovative multidisciplinary techniques to investigate the neurobiology underlying avoidant and restrictive eating, and that provides an ideal environment to develop future leaders in clinical research across disciplines. The training environment is outstanding in terms of didactic resources and availability of techniques to assess cross-disciplinary endpoints. Importantly, Dr. Thomas has a strong commitment from Psychology and Psychiatry leadership, and a cadre of multidisciplinary collaborators and senior advisors, who have enthusiastically endorsed her research program, mentoring, and K24 proposal. The specific research aims of the application are based on a recently funded R01 investigating the link between hormones, brain function and clinical features in adults with ARFID. Important new directions under the auspices of this award will feature multimodal neuroimaging, including assessment of brain structure (gray matter volume and white matter connectivity) and its relationship with functional brain abnormalities and clinical features. In the long-term, this K24 award will build capacity in the next generation of scholars to advance research in biobehavioral mechanisms of feeding and eating disorders.

项目总结/文摘