Mentorship in Biobehavioral Mechanisms of Avoidant/Restrictive Food Intake Disorder
回避/限制性食物摄入障碍的生物行为机制的指导
基本信息
- 批准号:10783916
- 负责人:
- 金额:$ 18.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-05 至 2028-08-30
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAmygdaloid structureAnisotropyAuthorshipAwardBehavior TherapyBody Weight decreasedBrainBrain imagingChildChokingChronicClinicalClinical ResearchClinical Trials DesignCorticospinal TractsCuesDataDedicationsDependenceDiffusion Magnetic Resonance ImagingDisciplineDoctor of PhilosophyEating DisordersEcological momentary assessmentEnvironmentEtiologyFoodFoundationsFrightFunctional Magnetic Resonance ImagingFunctional disorderFundingFutureGeneral HospitalsGoalsGrantHormonesHungerHyperactivityHypothalamic structureImpairmentIncubatorsInfrastructureInstitutionInterdisciplinary StudyLaboratoriesLeadershipLinkMaintenanceMalnutritionMapsMassachusettsMentorsMentorshipMid-Career Clinical Scientist Award (K24)National Institute of Mental HealthNegative ValenceNeurobiologyNeurocognitive DeficitNeurosecretory SystemsPaperPathway interactionsPatient CarePatternPerceptionPhenotypePsychiatryPsychologyPublicationsPublishingResearchResearch Domain CriteriaResearch PersonnelResourcesSensory DisordersSomatosensory CortexStrategic PlanningStructureSymptomsTaste PerceptionTechniquesTextureTimeTrainingVomitingWeightavoidant restrictive food intake disorderbiobehaviorbrain abnormalitiescareercareer developmentdietary supplementsdigital mental healthearly satietyexperiencefeedingfood avoidancefood restrictionfunctional disabilitygray matterinnovationinterestmedian forebrain bundlemedical schoolsmid-career facultymultidisciplinarymultimodal neuroimagingmultimodalityneuromechanismnext generationnovelpatient oriented researchprogramspsychosocialresponserestrictive eatingskillsstria terminaliswhite matter
项目摘要
PROJECT SUMMARY/ABSTRACT
The applicant, Jennifer J. Thomas, Ph.D., is the Co-Director of the Eating Disorders Clinical and Research
Program at Massachusetts General Hospital and Associate Professor of Psychiatry at Harvard Medical School.
Over the last decade Dr. Thomas’s research has focused on the pathophysiology and treatment of feeding and
eating disorders, particularly the newly recognized avoidant/restrictive food intake disorder (ARFID). Her
successful mentoring experience, publication record, and current funding demonstrate her commitment and
passion for patient-oriented research and provide an excellent foundation to accomplish the goals and objectives
of the proposed K24 Award. Dr. Thomas’s career development goals will enable her to (1) deepen her expertise
in multimodal neuroimaging techniques (integrating structural, functional, and diffusion MRI) to enhance her
multidisciplinary collaborations and ability to provide translational mentorship; (2) create a sustainable
infrastructure for continued research mentorship of diverse scholars to develop their own unique expertise within
ARFID that will extend beyond her laboratory and beyond the K24 period; and (3) bring together her two lines of
research (on behavioral treatment of ARFID and neurobiology of ARFID) to develop new treatments that modify
target neural mechanisms using advanced clinical trial designs. The proposed award will enable Dr. Thomas to
redistribute her effort to 30% mentorship; 60% research; and 10% patient care. Dr. Thomas will further establish
a patient-oriented research program that uses innovative multidisciplinary techniques to investigate the
neurobiology underlying avoidant and restrictive eating, and that provides an ideal environment to develop future
leaders in clinical research across disciplines. The training environment is outstanding in terms of didactic
resources and availability of techniques to assess cross-disciplinary endpoints. Importantly, Dr. Thomas has a
strong commitment from Psychology and Psychiatry leadership, and a cadre of multidisciplinary collaborators
and senior advisors, who have enthusiastically endorsed her research program, mentoring, and K24 proposal.
The specific research aims of the application are based on a recently funded R01 investigating the link between
hormones, brain function and clinical features in adults with ARFID. Important new directions under the auspices
of this award will feature multimodal neuroimaging, including assessment of brain structure (gray matter volume
and white matter connectivity) and its relationship with functional brain abnormalities and clinical features. In the
long-term, this K24 award will build capacity in the next generation of scholars to advance research in
biobehavioral mechanisms of feeding and eating disorders.
项目总结/文摘
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JENNIFER JOANNE THOMAS其他文献
JENNIFER JOANNE THOMAS的其他文献
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{{ truncateString('JENNIFER JOANNE THOMAS', 18)}}的其他基金
Evaluating the Utility of EDNOS as a Diagnostic Category
评估 EDNOS 作为诊断类别的实用性
- 批准号:
7155428 - 财政年份:2006
- 资助金额:
$ 18.69万 - 项目类别:
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