Synthesis ans Characterisation of Redox-active Dendrimers with patterned Periphery and Recognition Function for 2D and 3 D Materials. Construction kit with variable building blocks.

该项目的目标是合成一种新型的具有特定功能的树枝状大分子，在核心(氧化还原活性基质，即4，4-联吡啶单元)和外围(生物活性标记，即嘌呤或嘧啶碱基)具有识别功能，并研究其物理和化学性质以及生物底物与此类树枝状大分子系统的相互作用。该项目结合了外周可变官能度的聚合物核心在模块化系统意义上的结构可变性。通过这种方式，可以产生具有以下特性的新材料：(I)在特定识别反应中具有高选择性；(Ii)通过附着的氧化还原标记进行快速检测；(Iii)通过识别特性单独适应纳米级分子单元的设计；(Iv)具有局部氧化还原功能(电子/离子转移)的离子液晶特性；(V)通过与趋化因子受体CXCR4相互作用而产生的抗HIV-1/抗癌X4活性。

The project aims are the synthesis of a novel patterned dendrimers with a specific function into core (redox-active matrix i.e. 4,4-bipyridine units) and a recognition function on the periphery (a biologically active label i.e. purine or pyrimidine bases) and the study of the physical and chemical properties as well as the interaction between biological substrate and such dendrimer systems. The project combines a structural variability of the polymer cores of the variable functionality of the peripheral in the sense of a modular system.In this way, can be produced, new materials with: (i) a high selectivity at specific recognition reactions; (Ii) a rapid detection by the attached redox label; (Iii) individually adapted design of nanoscale, molecular units with high reproducibility by recognition properties; (Iv) ionic liquid crystal properties with localized redox functions (electron / ion transfer); (V) Anti-HIV-1 / anti-cancer X4 activities by interacting with the chemokine receptor CXCR4.