Spatiotemporal regulation of cell division and motility in Myxococcus xanthus (P01)

细菌中的时空控制机制可以动态地将蛋白质定位于不同的亚细胞位置，从而在空间上限制它们的活动。这些机制可以以细胞周期依赖或独立的方式工作。例如，分裂位点的定位是以依赖于细胞周期的方式控制的，以确保产生具有正确染色体组的大小正确的子细胞。相比之下，游动细菌的两极分化具有明显的前后极性，以实现有效的易位，并且这种极性可以独立于细胞周期而改变，以响应外部提示。在本项目中，我们重点研究了黄色粘球菌细胞分裂和运动的时空调控。

Spatiotemporal control mechanisms in bacteria operate to dynamically target proteins to distinct subcellular positions, thus spatially confining their activities. These mechanisms can operate in a cell cycle-dependent or -independent manner. For instance, positioning of the division site is controlled in a cell cycle-dependent manner to ensure the generation of correctly sized daughter cells with the correct chromosome complement. By contrast, motile bacteria are polarized with distinct front-rear polarity to enable efficient translocation and this polarity can change indepen-dently of the cell cycle in response to external cues. In this project, we focus on the spatiotemporal regulation of cell division and motility in Myxococcus xanthus.