Development of sustainable heterogeneous catalysts for step-efficient synthesis of selective oncology drug intermediates.

为发展该方案的多相催化方法，研究了（1）2-氨基苯甲酰胺衍生物脱氢选择性甲基化和还原胺化生成喹唑啉-4-胺衍生物，（2）1，2-二氨基苯衍生物与甲醇反应脱氢杂环化生成苯并咪唑衍生物，（3）甘油三酸酯水解为脂肪酸的反应正通过采用可持续的和环境友好的绿色合成方法得到证实。反应1和2的进一步优化、示范、动力学和机理研究正在进行中。对于反应3，我们已经提交了论文，正在审查中。

To develop the heterogeneous catalytic methods for the proposed plan, the reactions (1) Dehydrogenative selective methylation and reductive amination of 2-aminobenzamide derivative to quinazolin-4-amine derivative, (2) Dehydrogenative heterocyclization reaction of 1,2-diamino benzene derivative in reaction with methanol produced benzimidazole derivatives, and (3) Hydrolysis of triglycerides to fatty acids are being demonstrated by employing sustainable and environmentally benign green synthesis methods.For the reactions 1-3 we identified effective catalysts. Further optimization, demonstration, kinetics and mechanistic studies are underway for reactions 1 and 2. For the reaction 3 we have already submitted the paper and it is under review.