Konfokales Lasermikroskop

我们研究人类罕见的血液和免疫系统疾病，目的是揭示造血和免疫的分子机制。我们特别感兴趣的是研究先天免疫细胞内细胞内运输的动力学。为了分析和量化这些复杂和快速的过程，能够进行活细胞成像的最先进的高分辨率激光共聚焦显微镜是必不可少的核心设备。2015年夏天，库布斯研究中心的一台基本共聚焦显微镜与恩塞诺尔教授的团队一起被转移到杜塞尔多夫大学。属于AG Endres的基本共聚焦显微镜是可用的，但这种显微镜使用频繁，没有配备高灵敏度探测器。然而，为了推进我们正在进行和计划中的项目(由DFG、ERC、BMBF和其他公司资助)，额外的显微镜时间和提供最新技术进步的设备、高分辨率能力和最佳探测器质量是必不可少的先决条件。不仅是申请者，还有来自库布斯研究中心代表的各个学科的共同申请者都依赖于显微镜，并将从显微镜中获得巨大利润。

We study human rare diseases of the blood and the immune system with the aim to reveal molecular mechanisms of haematopoiesis and immunity. We are particularly interested in investigating the dynamics of intracellular transport within innate immune cells. To analyse and quantify these complex and rapid processes, a state-of-the-art high-resolution laser-confocal microscope with the possibility to perform live-cell imaging constitutes an essential core equipment. In summer 2015, a basic confocal microscope that had been present in the KUBUS Research Center was moved to the University of Düsseldorf together with the group of Prof. Ensenauer. A basic confocal microscope belonging to AG Endres is available, yet this microscope is heavily used and is not equipped with high sensitivity detectors. However, to advance our ongoing and planned projects (funded by DFG, ERC, BMBF and others), additional microscope time and a device offering the latest technical advancements, high resolution capacities and optimal detector quality are indispensable prerequisites. Not only the applicant, but also the co-applicants from across the disciplines represented in the KUBUS Research Center depend on and will highly profit from the microscope.