Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area.

干细胞移植提供了一种替代因急性中枢神经系统损伤或帕金森氏症等慢性退行性疾病而失去的神经细胞的方法。然而，到目前为止，结果一直令人失望，因为干细胞的分化、存活和整合很差，与使用胚胎作为干细胞来源有关的伦理问题令人困惑。这项研究中进行的实验将提供一些策略，以提高干细胞移植到受损中枢神经系统的效率，并开发使用自体骨髓干细胞进行修复。结果将是改善生物技术行业的移植方法和专业知识。

Stem cell transplantation offers a way to replace nerve cells lost due to acute CNS injury or chronic degenerative conditions such as Parkinson's Disease. However, to date, results have been disappointing because of poor differentiation, survival and integration of stem cells confounded by ethical issues associated with the use of embryos as the source of stem cells. The experiments conducted in this study will provide strategies to improve the efficacy of stem cell transplantation into the damaged CNS as well as developing the use of autologous bone marrow stem cells for repair. Outcomes will be improved transplant methodologies and expertise for the bio-technology industry.