Identification and characterization of major stem cell identity regulators within the epidermis (A13*)

表皮含有多种功能和空间上不同的干细胞群，它们在皮肤动态平衡、伤口愈合、衰老和疾病中发挥着重要作用。尽管它们在功能和医学上具有相关性，但大多数表皮干细胞群体在分子水平上仍然缺乏特征。使用最近建立的表观基因组学方法，促进对细胞异质性的分子解剖，我们的目标是揭示和功能表征驻留在表皮内的不同干细胞隔间的主要调节因子。

The epidermis contains a great variety of functionally and spatially distinct stem cell populations that play important roles during skin homeostasis, wound healing, ageing and disease. Despite their functional and medical relevance, most epidermis stem cell populations remain poorly characterized at a molecular level. Using a recently established epigenomic approach that facilitates the molecular dissection of cellular heterogeneity, we aim at uncovering and functionally characterizing the major regulators of the distinct stem cell compartments residing within the Epidermis.