Catalytic, Asymmetric Halogenations mediated by hypervalent Iodanes

碳卤素键是一种特殊的结构基序，通常会显著影响有机分子的独特性质。尽管卤化化合物具有巨大的用途，但选择性形成这种C、X键的方法仍然是一个主要挑战。高价碘最近被证明是烯烃溴化和氯化的有价值的工具。它们不仅是传统卤化试剂的一种无金属、温和的替代品，而且还提供了探索新颖而迷人的反应的机会，从而在卤化化学中开辟了新的结构空间。因此，在不对称氯化和溴化中应用这种有前途的高价碘化学是一个有益的目标，将在项目中通过结合高价碘和手性有机催化剂的优势来解决。

Carbon-halogen bonds constitute a privileged structural motif that often significantly influence the unique properties of organic molecules. Despite the tremendous utility of halogenated compounds, methods for the selective formation of such C,X bonds still constitute a major challenge. Hypervalent iodanes have lately proven to be valuable tools for the bromination and chlorination of alkenes. They are not only a metal-free, mild alternative to conventional halogenation reagents, but also offer the opportunity to explore novel and fascinating reactivities and thereby open new structural space within halogenation chemistry. Application of this promising hypervalent iodine chemistry in asymmetric chlorinations and brominations is thus a rewarding goal that will be addressed within the project by combining the advantages of hypervalent iodanes and chiral organocatalysts.