KFO 196: Signal Transduction in Adaptive and Maladaptive Cardiac Remodelling

在工业化国家，慢性心力衰竭是一个迅速增长的健康问题，是老年患者住院治疗的最常见诊断。然而，慢性心力衰竭的分子病理学仍不完全清楚，治疗选择有限。同样，房颤也是致病的主要原因之一，心力衰竭患者的房颤发生率明显增加，损害了患者的左心功能和临床预后。因此，萨尔兰大学的临床研究小组将进一步研究心室和心房心肌生理性和病理性重构的分子机制。

Chronic heart failure is a rapidly growing health problem in the industrialised countries and represents the most common diagnosis of hospital admission in elderly patients. However, the molecular pathology of chronic heart failure is still incompletely understood and therapeutic options are limited. Similarly, atrial fibrillation is a leading cause of morbidity, the incidence is markedly increased in patients with heart failure and impairs their left ventricular function as well as the clinical outcome. The Clinical Research Unit at the University of Saarland will therefore further characterise the molecular mechanisms of physiologic and pathologic remodelling of the ventricular and atrial myocardium.