Enantioselective Iron- or Cobalt-Catalyzed Hydrohydroxyalkylation of Butadiene

羰基的丁基化是有机化学中一个重要的过程，它为天然产物的全合成提供了基础，例如大量的聚酮类化合物。Krische组研究了钌或铱催化丁二烯的对映选择性氢化烷基化反应生成丁基化产物，这一反应具有很好的原子经济性。目前的项目将涉及将这种方法转移到廉价，毒性较小的铁或钴基催化剂上。因此，将开发一种无副产物、原子经济、无害环境、对工业应用具有高度吸引力的有价值的方法。

The crotylation of carbonyls is an important process in organic chemistry and enables the access to building blocks for the total synthesis of natural products such as the large and highly important class of polyketides. An enantioselective ruthenium- or iridium-catalyzed hydrohydroxyalkylation of butadiene forming crotylation products was developed in the Krische group which led to a process with perfect atom economy. The current project will involve the transfer of this methodology to inexpensive, less toxic, iron- or cobalt-based catalysts. Thus, a by-product free, atom economical, environmentally benign, valuable method with a high attractivity for industrial applications will be developed.