SFB 1350: Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk

慢性肾脏疾病(CKD)具有重要的医学和社会经济意义，并与高死亡率相关。CKD可由全身性疾病引起，如糖尿病和动脉高血压，也可由主要影响肾脏的疾病引起，如原发性肾小球疾病、肾小管缺陷和囊性肾脏疾病。不管CKD的根本原因是什么，肾小管系统和间质细胞在慢性肾脏疾病的发生发展中起着关键作用，因此在这种常见疾病的发病机制中具有中心地位。正常情况下，肾小管系统和间质的不同细胞类型以协调和微调的方式协同工作，从而使肾脏能够适应各种生理需求。重要的是，许多肾脏疾病过程也影响不止一种细胞类型，并在肾小管和间质中引起复杂的反应。这些过程可能会导致适应不良，并加剧疾病进展。其潜在的机制目前还知之甚少，检查肾小管细胞和间质细胞之间复杂的串扰的确切性质在技术上要求很高，需要综合的、多学科的方法。CRC1350的首要目标是使用全面和跨学科的策略，深入了解肾小管系统和肾间质的(病理)生理学。特别是，我们的目标是提高对不同类型细胞的不同功能及其在肾脏疾病进展和再生过程中的串扰的理解。基础研究人员和临床科学家之间的合作预期结果可以帮助确定新的靶点，并开发未来治疗慢性肾脏疾病的策略。

Chronic kidney disease (CKD) is of great medical and socio-economic significance and is associated with high mortality. CKD can result from either systemic diseases, such as diabetes mellitus and arterial hypertension, or diseases primarily affecting the kidney, such as primary glomerular diseases, tubular defects, and cystic kidney disease. Regardless of the underlying cause of CKD, the tubular system and interstitial cells are critically involved in either the development or progression of chronic kidney disease and thus have a central position in the pathogenesis of this common disease. Normally, the different cell types of the tubular system and interstitium work together in a coordinated and finely tuned way, thereby allowing the kidney to adapt to various physiological needs. Importantly, many renal disease processes also affect more than one cell type and elicit complex responses in tubules and interstitium. These processes can turn maladaptive and aggravate disease progression. The underlying mechanisms are yet poorly understood and examining the exact nature of the complex crosstalk between tubular cells and interstitial cells is technically demanding and requires an integrative, multidisciplinary approach. The overarching aim of CRC 1350 is to gain insights into the (patho-) physiology of the tubular system and the renal interstitium using a comprehensive and interdisciplinary strategy. In particular, we aim to improve understanding of the diverse functions of the various cell types and their crosstalk during disease progression and regeneration processes in the kidney. The expected results of the collaboration between basic researchers and clinical scientists can help identify novel targets and develop future therapeutic strategies for chronic kidney disease.