Synthetic biology tools for integration into bacterial chromosomes

该项目的目的是为细菌开发一套通用的染色体整合工具，使其能够快速开发新的生物产出。合成生物学这一新兴学科的一个主要目标是将工程原理应用于设计和构建新的生物实体，如蛋白质、基因电路和细胞。定制设计的遗传电路集成在适当的宿主基因组中，在从生物医学到生物燃料生产的各种应用中拥有巨大的经济潜力。该项目旨在帮助合成生物学家在适当的宿主细胞中嵌入定制电路，作为活工厂，有可能取代目前在环境和经济上代价高昂的工业过程。

The aim of the project is to develop a set of versatile chromosomal integration tools for bacteria, enabling rapid development of novel biological outputs. A major goal in the emerging discipline of synthetic biology is to apply engineering principles to the design and construction of new biological entities such as proteins, genetic circuits and cells. Custom-designed genetic circuits, integrated in an appropriate host genome, hold enormous economic potential for applications ranging from biomedicine to biofuel production. This project aims to help synthetic biologists to embed made-to-order circuits in appropriate host cells to act as living factories, potentially replacing industrial processes which are currently environmentally and economically costly.