Understanding Mitotic Telomere Deprotection

该项目旨在研究端粒，即保护染色体末端的DNA和蛋白质结构。在细胞分裂过程中，处于压力下的细胞会有意地解开它们的端粒。该项目希望产生新的知识，挑战端粒作为静态元素的传统观念，表明端粒可以是动态信号中心。该项目的预期结果包括对这种新现象所涉及的遗传、蛋白质组学和信号通路的理解。这将为我们对保护人类基因组的生物过程的基本理解提供显著的好处，并为端粒生物学、DNA修复和基因组稳定性的研究提供有价值的数据集。

This project aims to study telomeres, the DNA and protein structures that protect chromosome ends. During cell division, cells under stress intentionally uncap their telomeres. This project expects to generate new knowledge that challenges the conventional notion of telomeres as static elements, showing instead that telomeres can be dynamic signalling hubs. Expected outcomes of this project include an understanding of the genetic, proteomic, and signalling pathways involved in this novel phenomenon. This should provide significant benefits to our fundamental understanding of biological processes that protect human genomes and provide a valuable dataset for research on telomere biology, DNA repair, and genome stability.