Synthesis and Applications of Antifreeze Proteins and Glycoproteins

许多细胞在低于体温时会被损坏，从而限制了应用的保质期。例如，人类血小板在22度下的储存时间限制为5天。这项研究将产生可用于农业领域（体外受精技术，改进血液系统的开发），水产养殖和人类生殖技术的分子，冰晶生长和冷冻是破坏性的。这一成果将通过合成模拟天然产物的分子来实现，这些天然产物使鱼类能够在冰冷的北极和北冰洋中生存，并研究它们如何能够在这些极端环境中保护细胞和组织免受损害。

Many cells are damaged when they are chilled below body temperatures thus limiting shelf-life for applications. For example, storage of human blood platelets is limited to 5 days at 22 degrees. This research will produce molecules that can be used in the fields of agriculture (in vitro fertilization techniques, development of improved blood lines), aquaculture and human reproductive technologies, where ice crystal growth and freezing are damaging. This outcome will be achieved by the synthesis of molecules that mimic natural products that allow fish to survive in the icy Arctic and Arctic Oceans and study how they are able to protect cells and tissues from damage in these extreme environments.