Targeting DNA with Dynamic Combinatorial Chemistry

利用动态组合化学靶向 DNA

• 批准号: DP0984695
• 负责人: Prof Margaret Harding
• 金额: $ 22.5万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0984695
• 关键词: Targeting; DNA; Dynamic; Combinatorial; Chemistry

The interaction of molecules with DNA, the molecule that controls genetic information, is fundamental to drug design, diagnosis of disease and the environment. Chemists usually synthesise these molecules in the laboratory. We will use an innovative new approach to producing molecules that interact with DNA, that as fast and efficient and mirrors the processes used by Nature to make natural products. This research may lead to the design of new therapeutics, diagnostics and applications that will benefit the Australian community, and will provide excellent training of researchers in skills required for employment in the biotechnology and pharmaceutical fields.

分子与DNA（控制遗传信息的分子）的相互作用是药物设计、疾病诊断和环境的基础。化学家通常在实验室合成这些分子。我们将使用一种创新的新方法来生产与DNA相互作用的分子，这种方法既快速又有效，并反映了大自然用于制造天然产品的过程。这项研究可能会导致设计新的疗法，诊断和应用，这将有利于澳大利亚社会，并将提供良好的培训研究人员在生物技术和制药领域就业所需的技能。