Exploration of cause of death and acute phase treatment for carbondioxide poisoning

通过实际案例和灾害认识到CO2中毒的危险性，但尚未揭示CO2中毒死亡的机理和直接原因。为了探讨死亡原因，我们建立了模型大鼠，并测量了大鼠的血流动力学、血气分析和腔内CO2和O2的浓度。献祭后，我们分离了组织并分析了一些分子生物学数据。本研究的目的是确定血液中CO2浓度上限，阐明CO2中毒的机制，这对我们来说是非常具有挑战性的。

The hazardousness is recognized in CO2 poisoning by real cases and disasters, however the mechanism and the direct cause of CO2 poisoning death are not revaeled. To investigate the cause of death, we established model rats and time-dependently measured hemodynamics, blood gas analysis in rats and theconcentration of CO2 and O2 in the chamber. After the sacrifice, we isolated the tissues and analyzed some molecular biological data. This study is very challenging for us to aim to determine the upper limitation of CO2 concentration in the blood and elucidate the mechanism of CO2 poisoning.