Mechanism of tumorigenesis in mast cells

肥大细胞在免疫应答中具有重要作用。它们的增殖受到与细胞因子结合的各种受体的严格调节。众所周知，受体的组成性激活导致肥大细胞肿瘤。然而，肥大细胞肿瘤发生的确切机制尚未完全了解。最近，我们建立了具有肥大细胞瘤特征的肥大细胞系。利用微阵列分析和生化分析，我们获得了一些新的发现，肥大细胞肿瘤的过程。

Mast cells have an important role in immune responses. Their proliferation is tightly regulated by various receptors that bind to cytokines. It is well known that constitutively activations of the receptors lead to mast cell tumors. However, the precise mechanism of the tumorigenesis of mast cells is not fully understood. Recently, we established a mast cell lines that have characteristic features of a mast cell tumor. Using microarray analyses and biochemical analyses, we obtained some novel findings about the process of mast cell tumorigenesis.