Synthesis of high-strength tissue invasive bone substitute materials by unidirectional freezing and development of control method of their porous structure

制备了含有羟基磷灰石(HAP)颗粒和磷酸三钙(TCP)颗粒的有机浆料。然后对有机浆料进行单向冷冻、冷冻干燥、空气中焙烧，合成了HAP或TCP整体。在使用间苯二酚-甲醛(RF)凝胶作为有机浆料的情况下，整体孔径和抗压强度分别为0.1 mm和2.3 Mpa。当以叔丁醇和聚乙烯吡咯烷酮为溶剂和粘结剂时，可制得孔径大于0.1 mm、抗压强度大于10 Mpa的羟基磷灰石或磷酸三钙微球。此外，还提出了一种利用单向冻结模拟控制整体孔结构的方法。

Organic slurry containing hydroxyapatite (HAP) particles or tricalcium phosphate (TCP) particles was prepared. Then HAP or TCP monolith was synthesized by unidirectional freezing of the organic slurry, freeze-drying, and calcination in air. In the case where resorcinol-formaldehyde (RF) gel was used as organic slurry, the pore size and compressive strength of monolith are 0.1mm and 2.3MPa. However, the compressive strength was not enough for a practical use.When t-butanol and polyvinylpyrrolidone were used as solvent and binder, it was possible to produce HAP or TCP monolith having pore size of more than 0.1mm and a compressive strength of more than 10MPa. In addition, a method controlling the porous structure of the monolith was proposed with the help of unidirectional freezing simulation.