Circadian rhythmic control of differentiation of human stem cells

定量地阐明了不同的培养操作对昼夜节律基因表达再振荡的影响，特别是对振荡的幅度和相位的影响。再振荡开始的阶段取决于培养操作的种类，包括培养基更换、添加葡萄糖、大量血清和地塞米松，这些认识不仅有助于研究再振荡的机制，也有助于调控昼夜基因表达振荡的方法学。

The effects of various cultivation operation on re-oscillation of circadian gene expression , especially on amplitude and phase of oscillation, were quantitatively clarified. The phase at the beginning of re-oscillation depended on the kind of cultivation operation including medium change, additions of glucose, large amount of serum, and dexamethasone, which knowledge might contribute on not only the study about the mechanism of re-oscillation but also the control methodology of the oscillation of circadian gene expression.