Biosynthtic investigation of the didemnins

最早从加勒比海被囊藻Trididemnum Solidum中发现的抗癌多肽Didemnins最近在世界各地采集的海洋细菌Tistrella mobilis中得到了鉴定。因此，我们比较了衣状菌和微生物的产量和遗传图谱。我们发现细菌的代谢模式与被膜细菌的代谢模式有很大的不同。对被囊藻中微生物区系的分析表明，蓝藻属是被囊藻的主要伴生菌，而运动囊藻则是与寄主共生的次要微生物。

The antitumor peptide didemnins originally found from the Caribbean tunicate Trididemnum solidum were recently identified in the cultured marine bacterium Tistrella mobilis collected in various regions in the world. We thus compared the production and genetic profiles between the tunicate and the microbe. We found that the metabolic pattern in the bacteria differed largely from that of the tunicate. Analysis of microbial fauna in the tunicate indicated that a genus of cyanobacteria is a main associate of the tunicate, but T. mobilis was found as only a minor microbe that associate with the host.