Exploration of immunological risk factors for osteoporosis

本研究的目的是在流行病学研究中探索骨质疏松症及其相关健康状况的潜在危险因素。检测血清中的免疫和炎症标志物，并检测其与骨量和认知功能的关系。在Yokogoshi研究中，血清巨细胞病毒抗体滴度与脊柱骨密度显著相关（r=-0.12），在Yamato研究中，巨细胞病毒抗体滴度与简易精神状态检查评分的2年变化显著相关（r=0.30）。它的结论是，以前的病毒感染可以预测骨质疏松症和/或认知能力下降。

The aim of the study was to explore potential risk factors for osteoporosis and its related health conditions in epidemiologic studies. Immunological and inflammation markers in serum were measured, and their associations with bone mass and cognitive function were tested. Serum Cytomegalovirus antibody titers were significantly correlated with spinal bone mineral density in the Yokogoshi Study (r=-0.12), and Cytomegalovirus antibody titers were significantly correlated with 2-year changes in Mini-Mental State Examination scores in the Yamato Study (r=0.30). It is concluded that previous viral infection could predict osteoporosis and/or cognitive decline.