A novel ultrasound imaging for pancreatic cancer using tumor directed-contrast media

胰腺导管癌（PDAC）由于缺乏有效的早期诊断手段，预后极差。我们最近开发了一种使用岩藻糖受体介导的内吞作用的新型PDAC靶向纳米颗粒（PLoS ONE，2012）。我们的携带抗癌药物的纳米颗粒可以特异性地将药物递送到PDAC细胞并抑制肿瘤生长。然后，我们利用这种策略诊断PDAC作为一种新的超声成像。我们将全氟丁烷（PFB）封装到我们的纳米颗粒中，并成功地使用超声超声成像将PDAC作为异种移植大鼠模型中的肿瘤。

Patients with pancreatic ductal carcinoma (PDAC) are dismal prognosis due to absence of effective modality to diagnose at early stage. We have recently developed a novel targeting nanoparticle for PDAC using fucose receptor mediated-endocytosis (PLoS ONE, 2012). Our nanoparticles carrying anti-cancer drugs could specifically delivered agents to PDAC cells and suppressed tumor growth. We then utilized this strategy for diagnosing PDAC as a novel ultrasound imaging. We encapsulated perfulbutane (PFB) into our nanoparticles and succeeded to image PDAC as a tumor in xenografted rat model using ultrasound sonography.