Development of boron trace drug with broad molecule pursuit and destructive power by neutron irradiation

本研究的目的是利用中子辐照开发一种具有广泛分子追踪力和破坏力的硼微量药物。我们利用硼修饰的crucumin UTX-51和热中子对BSA和糖化BSA进行了AGE模型的破坏，并用鸡蛋模型对UTX-51进行了药代动力学分析。结果表明，UTX-51在与热中子结合时能有效地破坏BSA和糖基化BSA。此外，从药代动力学分析显示UTX-51穿过血脑屏障，也分布在脑内。因此，UTX-51作为一种微量硼药物更有前景，有人建议它可以成为阿尔茨海默病的候选药物。

The purpose of this research is to development a boron trace drug with broad molecule pursuit and destructive power by neutron irradiation. We performed the destruction of BSA and glycated BSA as a AGE model using boron-modified crucumin UTX-51 and thermal neutron, and pharmacokinetic analysis of UTX-51 by a chicken egg model. It turned out that UTX-51 destroys BSA and the glycated BSA efficiently at the combined with a thermal neutron. Moreover, it revealed that UTX-51 passing through a blood brain barrier and also being distributed in a brain from the pharmacokinetic analysis. Therefore, UTX-51 is more promising as a boron trace drug, and it was suggested that it can become a candidate for Alzheimer's disease.