Development of novel vascular anastomosis device with biodegradable stent

在这项研究中，我们开发了一种新的血管吻合技术，用于严重动脉粥样硬化患者，难以手工直接血管缝合技术。 我们研究了使用生物可吸收增强材料和氰基丙烯酸酯，在猪颈动脉的离体研究中，我们证实了生物可吸收支架和缝合方法在机械延伸测试和水爆破压力测试中均比传统的直接血管缝合方法具有更好的强度。 另一方面，我们无法避免在犬模型的体内研究中发生急性血栓闭塞。 我们认为，通过解决血栓问题，我们可以期待未来的临床应用。

In this study, we developed the novel technique of vascular anastomosis for severe atherosclerosis patient that had difficulty in manual direct vascular suture technique. We examined to use bioabsorbable reinforcement material and cyanoacrylate.In ex vivo study with porcine carotid artery, we confirmed better strength of biodegradable stent and bioglue method compare to conventional direct vascular suture method in both of the mechanical extension test and the water burst pressure test. On the other hand, we could not avoid acute thrombotic occlusion in vivo study with canine model. We think that we can expect for future clinical application by solving this thrombosis problem.